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Objectives: To conduct a systematic review and meta-analysis regarding the efficacy and safety of inhaled corticosteroids for COPD exacerbations. Methods: We searched the following electronic databases (PubMed, EMBASE, PubMed, Cochrane Central Register of Controlled Trials, Cochrane Subsystem for Review of Clinical Trials and PsycINFO): AMEDLINE, the Cochrane Central Register of Controlled Trials, PUBMED, CINAHL, CINHAP, AMED, Cochrane Controlled Trials Register, CENTRAL, CAB Abstracts, and the Internet, sarms for sale california. Two authors independently retrieved documents with additional criteria, and extracted data for each of the studies. Results: We identified 23 randomized, placebo-controlled trials, 19 randomized-controlled trials on adjunctive steroids for COPD exacerbations (nine controlled), seven randomized, double-blind studies, 9 multicentrin trials, 10 observational studies and 3 other studies, sarms for sale canada. In total, 898,730 people received 3,800,000 parenteral doses of corticosteroids in 893,769 individuals. Seven studies included COPD patients who received either no steroid or corticosteroid alone (n=11). Twelve studies were observational and three trials were experimental, sarms for sale california. At 6-month follow-up, mean changes in pulmonary function in treated and placebo-treated patients showed statistically significant decreases in total pulmonary function, and mean increases in submaximal left ventricular function and diastolic blood pressure, elite sarms review. CONCLUSIONS: The findings suggest no differences in effectiveness of inhaled corticosteroids between studies that have used control groups of individuals not prescribed steroids, and those that used patients prescribed steroids, sarms for sale science bio. The benefits of inhaled corticosteroids should vary with asthma severity and COPD duration. This evidence must inform clinicians of the current situation with respect to use and potential adverse effects in asthma and COPD. Copyright © 2015, The Authors. Published by Elsevier Inc. All rights reserved, sarms elite review.
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